PARP10

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors.

Full Name

Poly(ADP-Ribose) Polymerase Family Member 10

Function

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379).
In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833).
Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125).
Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737).

Biological Process

NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Negative regulation of fibroblast proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein K63-linked ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of viral genome replicationManual Assertion Based On ExperimentIMP:UniProtKB
Protein ADP-ribosylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein auto-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein mono-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein poly-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of chromatin assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Translesion synthesisManual Assertion Based On ExperimentIDA:UniProtKB
Viral protein processingTAS:Reactome

Cellular Location

Nucleus, nucleolus
Cytoplasm
Shuttles between the nuclear and cytoplasmic compartment (PubMed:15674325).
A subpopulation concentrates in the nucleolus during late G1/S phase (PubMed:15674325).

PTM

Stimulated through its phosphorylation by CDK2 (PubMed:16455663).
Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions (PubMed:16455663).
Phosphorylation is suppressed in growth-arrested cells (PubMed:16455663).
Auto-mono-ADP-ribosylated on glutamate and lysine residues.