PDE4A

PDE4A belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Full Name
PDE4A
Function
Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Publications
Isoform 1
Efficiently hydrolyzes cAMP.
Isoform 2
Efficiently hydrolyzes cAMP.
Isoform 3
Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP.
Isoform 4
Efficiently hydrolyzes cAMP.
Isoform 6
Efficiently hydrolyzes cAMP.
Isoform 7
Efficiently hydrolyzes cAMP.
Biological Process
cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to xenobiotic stimulusIEA:Ensembl
G protein-coupled receptor signaling pathwayTAS:Reactome
Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Regulation of protein kinase A signalingIEA:Ensembl
Sensory perception of smellIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Cytoplasm, perinuclear region
Isoform 2
Cytoplasm, perinuclear region
Cell projection, ruffle membrane
Isoform 3
Cytoplasm, cytosol
Isoform 4
Membrane ; Peripheral membrane protein
Isoform 4 has propensity for association with membranes.
Isoform 6
Cytoplasm, perinuclear region
Isoform 7
Cytoplasm, cytosol
Membrane ; Peripheral membrane protein
Predominantly cytosolic.
PTM
Isoform 1
Proteolytically cleaved by CASP3.
Isoform 2
Phosphorylated at Ser-119 by PKA.
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Anti-PDE4A antibodies

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Mouse Anti-PDE4A Recombinant Antibody (6B6) (CBMAB-P1211-YC)

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Target: PDE4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B6
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-PDE4A Recombinant Antibody (5C6) (CBMAB-P1210-YC)

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Target: PDE4A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5C6
Application*: F, IF, IH
Datasheet SDS

Mouse Anti-PDE4A Recombinant Antibody (3D4) (CBMAB-P1209-YC)

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Target: PDE4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D4
Application*: F, IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-PDE4A Recombinant Antibody (1E3) (CBMAB-P1208-YC)

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Target: PDE4A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1E3
Application*: F, IC, IF, WB
Datasheet SDS

Mouse Anti-PDE4A Recombinant Antibody (1C8) (CBMAB-P1207-YC)

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Target: PDE4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C8
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-PDE4A Recombinant Antibody (4E1.16) (CBMAB-0221-CN)

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Target: PDE4A
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 4E1.16
Application*: IF, IH, WB
Datasheet SDS

Mouse Anti-PDE4A Recombinant Antibody (4B5.13) (CBMAB-0210-CN)

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Target: PDE4A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4B5.13
Application*: WB
Datasheet SDS

Mouse Anti-PDE4A Recombinant Antibody (4-34.10) (CBMAB-0192-CN)

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Target: PDE4A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 4-34.10
Application*: WB
Datasheet SDS

Mouse Anti-PDE4A Recombinant Antibody (1-21.2) (CBMAB-0001-CN)

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Target: PDE4A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1-21.2
Application*: IF, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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