PDZD2

PDZD2 contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.

PDZ Domain Containing 2

Cell adhesionIEA:UniProtKB-KW

Nucleus
Cytoplasm
Endoplasmic reticulum
At cell-cell contacts in lung epithelial cells.
Processed PDZ domain-containing protein 2
Secreted

A secreted form is produced by caspase-mediated proteolytic cleavage.