PES1

PES1 is a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity.

Full Name

Pescadillo ribosomal biogenesis factor 1

Function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Biological Process

Cell population proliferationManual Assertion Based On ExperimentIMP:MGI
Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Manual Assertion Based On ExperimentIMP:UniProtKB
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Manual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Ribosomal large subunit biogenesis2 PublicationsIC:UniProtKB
rRNA processingManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Nucleus, nucleolus
Nucleus, nucleoplasm
Chromosome
Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli.

PTM

Sumoylated.