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Mouse Anti-PES1 Recombinant Antibody (H-10) (CBMAB-P1464-YC)

Provided herein is a Mouse monoclonal antibody against Human Pescadillo ribosomal biogenesis factor 1. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PES1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
H-10
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pescadillo ribosomal biogenesis factor 1
Introduction
PES1 is a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity.
Entrez Gene ID
Human23481
Mouse64934
Rat289740
UniProt ID
HumanO00541
MouseQ9EQ61
RatQ3B8N8
Alternative Names
PES
Function
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Biological Process
Cell population proliferationManual Assertion Based On ExperimentIMP:MGI
Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Manual Assertion Based On ExperimentIMP:UniProtKB
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Manual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Ribosomal large subunit biogenesis2 PublicationsIC:UniProtKB
rRNA processingManual Assertion Based On ExperimentIMP:MGI
Cellular Location
Nucleus, nucleolus
Nucleus, nucleoplasm
Chromosome
Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli.
PTM
Sumoylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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