Mouse Anti-PES1 Recombinant Antibody (H-10) (CBMAB-P1464-YC)

Name: Mouse Anti-PES1 Recombinant Antibody (H-10)
SKU: CBMAB-P1464-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

H-10

Application

WB, IP, IF, ELISA

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Pescadillo ribosomal biogenesis factor 1

Introduction

PES1 is a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity.

Entrez Gene ID

Human	23481
Mouse	64934
Rat	289740

UniProt ID

Human	O00541
Mouse	Q9EQ61
Rat	Q3B8N8

Alternative Names

PES

Function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Biological Process

Cell population proliferationManual Assertion Based On ExperimentIMP:MGI
Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Manual Assertion Based On ExperimentIMP:UniProtKB
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Manual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Ribosomal large subunit biogenesis2 PublicationsIC:UniProtKB
rRNA processingManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Nucleus, nucleolus
Nucleus, nucleoplasm
Chromosome
Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli.

PTM

Sumoylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-PES1 Recombinant Antibody (G-11) (CAT#: CBMAB-P1463-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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