PIGW

Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 [PubMed 14517336]).[supplied by OMIM

Full Name

phosphatidylinositol glycan anchor biosynthesis, class W

Function

Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057).
Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity).

Biological Process

GPI anchor biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
GPI anchor metabolic process1 PublicationIC:UniProtKB
Preassembly of GPI anchor in ER membraneTAS:Reactome
Protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Glycosylphosphatidylinositol biosynthesis defect 11 (GPIBD11):
An autosomal recessive neurologic disorder characterized by developmental delay, mental retardation, tonic seizures associated with hypsarrhythmia, dysmorphic facial features, and elevated serum alkaline phosphatase.