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Mouse Anti-PIGW Recombinant Antibody (1D8) (CBMAB-P1773-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphatidylinositol Glycan Anchor Biosynthesis Class W. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PIGW antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D8
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphatidylinositol glycan anchor biosynthesis, class W
Introduction
PIGW is an inositol acyltransferase that acylates the inositol ring of phosphatidylinositol. This occurs in the endoplasmic reticulum and is a step in the biosynthesis of glycosylphosphatidylinositol (GPI), which anchors many cell surface proteins to the membrane. Defects in this gene are a cause of the age-dependent epileptic encephalopathy West syndrome as well as a syndrome exhibiting hyperphosphatasia and cognitive disability (HPMRS5).
Entrez Gene ID
284098
UniProt ID
Q7Z7B1
Alternative Names
Phosphatidylinositol Glycan Anchor Biosynthesis Class W; Phosphatidylinositol-Glycan Biosynthesis Class W Protein; Phosphatidylinositol Glycan, Class W; EC 2.3.-.-; HPMRS5; PIG-W; Gwt1;
Function
Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057).
Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity).
Biological Process
GPI anchor biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
GPI anchor metabolic process1 PublicationIC:UniProtKB
Preassembly of GPI anchor in ER membraneTAS:Reactome
Protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Glycosylphosphatidylinositol biosynthesis defect 11 (GPIBD11):
An autosomal recessive neurologic disorder characterized by developmental delay, mental retardation, tonic seizures associated with hypsarrhythmia, dysmorphic facial features, and elevated serum alkaline phosphatase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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