PIK3C3

PIK3C3 has ubiquitous expression in testis (RPKM 7.2), brain (RPKM 7.0) and 25 other tissues.

Full Name

phosphatidylinositol 3-kinase catalytic subunit type 3

Function

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:7628435, PubMed:33637724).
As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950).
Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123).
Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity).
Required for transport from early to late endosomes (By similarity).
(Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication.

Biological Process

Autophagosome assemblyManual Assertion Based On ExperimentIBA:GO_Central
Autophagosome maturationManual Assertion Based On ExperimentIDA:ComplexPortal
AutophagyManual Assertion Based On ExperimentIMP:MGI
Autophagy of peroxisomeManual Assertion Based On ExperimentIBA:GO_Central
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
Cellular response to glucose starvationISS:UniProtKB
Early endosome to late endosome transportManual Assertion Based On ExperimentIDA:ComplexPortal
EndocytosisManual Assertion Based On ExperimentIBA:GO_Central
Endosome organizationIEA:Ensembl
MacroautophagyISS:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol-3-phosphate biosynthetic processManual Assertion Based On ExperimentIDA:ComplexPortal
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Protein lipidationManual Assertion Based On ExperimentIMP:MGI
Protein localization to phagophore assembly siteIEA:Ensembl
Protein phosphorylationManual Assertion Based On ExperimentIDA:ComplexPortal
Protein processingIEA:Ensembl
Protein targeting to lysosome1 PublicationIC:ComplexPortal
Regulation of autophagyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of macroautophagyManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of protein secretionIEA:Ensembl
Response to leucineIEA:Ensembl

Cellular Location

Midbody
Late endosome
Cytoplasmic vesicle, autophagosome
As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358).
Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity).

PTM

Ubiquitinated via 'Lys-29'- and 'Lys-48'-linked ubiquitination by UBE3C, promoting its degradation (PubMed:33637724).
Deubiquitination by ZRANB1/TRABID promotes its stabilization, leading to autophagosome maturation (PubMed:33637724).