PLA2G1B

This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response.

phospholipase A2, group IB, pancreas

Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:10681567, PubMed:17603006).
Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:10681567, PubMed:17603006).
May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity).
May act in an autocrine and paracrine manner (PubMed:7721806, PubMed:25335547).
Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed:25335547).
Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).

Actin filament organizationManual Assertion Based On ExperimentTAS:ProtInc
Activation of phospholipase A2 activityManual Assertion Based On ExperimentTAS:BHF-UCL
Antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Arachidonic acid secretionManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular response to insulin stimulusBy SimilarityISS:BHF-UCL
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Fatty acid biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Innate immune response in mucosaManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionBy SimilarityISS:BHF-UCL
Leukotriene biosynthetic processBy SimilarityISS:BHF-UCL
Lipid catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Neutrophil chemotaxisBy SimilarityISS:BHF-UCL
Neutrophil mediated immunityBy SimilarityISS:BHF-UCL
Phosphatidylcholine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylglycerol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of calcium ion transport into cytosolBy SimilarityISS:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of fibroblast proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of immune responseBy SimilarityISS:BHF-UCL
Positive regulation of interleukin-8 productionBy SimilarityISS:BHF-UCL
Positive regulation of MAP kinase activityBy SimilarityISS:BHF-UCL
Positive regulation of NF-kappaB transcription factor activityBy SimilarityISS:BHF-UCL
Positive regulation of podocyte apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein secretionManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Regulation of glucose importBy SimilarityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Secreted
Secreted from pancreatic acinar cells in its inactive form.

Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.