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Mouse Anti-PLA2G1B Recombinant Antibody (2B7) (CBMAB-A6768-LY)

The product is antibody recognizes PLA2G1B. The antibody 2B7 immunoassay techniques such as: WB, ELISA.
See all PLA2G1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B7
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
PLA2G1B (AAH05386, 17 a.a. ~ 70 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phospholipase A2, group IB, pancreas
Introduction
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]).[supplied by OMIM
Entrez Gene ID
5319
UniProt ID
P04054
Alternative Names
MGC119834; MGC119835; PLA2; PLA2A; PPLA2
Function
Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:10681567, PubMed:17603006).
Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:10681567, PubMed:17603006).
May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity).
May act in an autocrine and paracrine manner (PubMed:7721806, PubMed:25335547).
Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed:25335547).
Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).
Biological Process
Actin filament organizationManual Assertion Based On ExperimentTAS:ProtInc
Activation of phospholipase A2 activityManual Assertion Based On ExperimentTAS:BHF-UCL
Antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Arachidonic acid secretionManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular response to insulin stimulusBy SimilarityISS:BHF-UCL
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Fatty acid biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Innate immune response in mucosaManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionBy SimilarityISS:BHF-UCL
Leukotriene biosynthetic processBy SimilarityISS:BHF-UCL
Lipid catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Neutrophil chemotaxisBy SimilarityISS:BHF-UCL
Neutrophil mediated immunityBy SimilarityISS:BHF-UCL
Phosphatidylcholine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylglycerol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of calcium ion transport into cytosolBy SimilarityISS:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of fibroblast proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of immune responseBy SimilarityISS:BHF-UCL
Positive regulation of interleukin-8 productionBy SimilarityISS:BHF-UCL
Positive regulation of MAP kinase activityBy SimilarityISS:BHF-UCL
Positive regulation of NF-kappaB transcription factor activityBy SimilarityISS:BHF-UCL
Positive regulation of podocyte apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein secretionManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Regulation of glucose importBy SimilarityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Secreted from pancreatic acinar cells in its inactive form.
PTM
Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
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For research use only. Not intended for any clinical use.

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