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PLAUR

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq]
Full Name
PLAUR
Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Biological Process
Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:CACAO
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Negative regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of DNA bindingManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of homotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIMP:CACAO
Regulation of cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of fibrinolysis1 PublicationIC:ComplexPortal
Regulation of plasminogen activation1 PublicationIC:ComplexPortal
Regulation of proteolysis1 PublicationNAS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Urokinase plasminogen activator signaling pathway1 PublicationIC:ComplexPortal
Cellular Location
Cell membrane
Cell projection, invadopodium membrane
Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
Isoform 1
Cell membrane
Isoform 2
Secreted

Anti-PLAUR antibodies

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Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0235
Application*: F, C, P, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0229
Application*: C, P, WB
Target: PLAUR
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2824
Application*: F
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: VIM5
Application*: F
Target: PLAUR
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0941
Application*: F
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBFYC-3037
Application*: WB, IC, P, C, E, IP, IF, F
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F11
Application*: WB, E
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R-5
Application*: E
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R-4
Application*: WB, FC, E, IH, P, C, MC
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R-3
Application*: WB, E
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: IIIB6
Application*: FC, P, W
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: IIIB11
Application*: FC, C, P, WB
Target: PLAUR
Host: Rabbit
Specificity: Human
Clone: D7X2N
Application*: WB, IF
Target: PLAUR
Host: Rabbit
Specificity: Human
Clone: D4Q5S
Application*: WB, IP
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9B5
Application*: E, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9B17
Application*: E, FC, IH, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9B16
Application*: E, IH
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9
Application*: E
Target: PLAUR
Host: Mouse
Specificity: Human
Clone: 8B51
Application*: E, FC, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 18L1
Application*: FC, N, WB
Target: PLAUR
Host: Rabbit
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L969
Application*: WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L968
Application*: FC, N, WB
Target: PLAUR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 103
Application*: E
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 62022
Application*: WB, FC, E
Target: PLAUR
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 109801
Application*: WB, FC
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P423
Application*: E, WB, IH
Target: PLAUR
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 8B50
Application*: E, F, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D6
Application*: E, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 13H210
Application*: IF
Target: PLAUR
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 10K37
Application*: F
Target: PLAUR
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 7J34
Application*: WB
Target: PLAUR
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-C1616
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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