PLAUR
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Full Name
plasminogen activator, urokinase receptor
Function
Acts as a receptor for urokinase plasminogen activator (PubMed:15677461).
Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Biological Process
Blood coagulation
Chemotaxis
Negative regulation of apoptotic process
Negative regulation of intrinsic apoptotic signaling pathway
Positive regulation of DNA binding
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of homotypic cell-cell adhesion
Positive regulation of protein phosphorylation
Positive regulation of release of cytochrome c from mitochondria
Regulation of cell adhesion
Regulation of fibrinolysis
Regulation of plasminogen activation
Regulation of proteolysis
Signal transduction
Urokinase plasminogen activator signaling pathway
Chemotaxis
Negative regulation of apoptotic process
Negative regulation of intrinsic apoptotic signaling pathway
Positive regulation of DNA binding
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of homotypic cell-cell adhesion
Positive regulation of protein phosphorylation
Positive regulation of release of cytochrome c from mitochondria
Regulation of cell adhesion
Regulation of fibrinolysis
Regulation of plasminogen activation
Regulation of proteolysis
Signal transduction
Urokinase plasminogen activator signaling pathway
Cellular Location
Cell membrane
Cell projection, invadopodium membrane
Note: Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
Isoform 1
Cell membrane
Isoform 2
Secreted
Cell projection, invadopodium membrane
Note: Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
Isoform 1
Cell membrane
Isoform 2
Secreted
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Anti-PLAUR antibodies
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CompareTarget: PLAUR
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 10K37
Application*: F
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2E2
Application*: E, IF, F
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2333
Application*: F
Target: PLAUR
Specificity: Human
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F11
Application*: WB, E
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0235
Application*: F, C, P, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0229
Application*: C, P, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R-5
Application*: E
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R-4
Application*: WB, FC, E, IH, P, C, MC
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R-3
Application*: WB, E
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: IIIB6
Application*: FC, P, W
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: IIIB11
Application*: FC, C, P, WB
Target: PLAUR
Host: Rabbit
Specificity: Human
Clone: D7X2N
Application*: WB, IF
Target: PLAUR
Host: Rabbit
Specificity: Human
Clone: D4Q5S
Application*: WB, IP
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9B5
Application*: E, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9B17
Application*: E, FC, IH, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9B16
Application*: E, IH
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9
Application*: E
Target: PLAUR
Host: Mouse
Specificity: Human
Clone: 8B51
Application*: E, FC, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 18L1
Application*: FC, N, WB
Target: PLAUR
Host: Rabbit
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L969
Application*: WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L968
Application*: FC, N, WB
Target: PLAUR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 103
Application*: E
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 62022
Application*: WB, FC, E
Target: PLAUR
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 109801
Application*: WB, FC
Target: PLAUR
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-C1616
Application*: WB
Target: PLAUR
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2824
Application*: F
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: VIM5
Application*: F
Target: PLAUR
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0941
Application*: F
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P423
Application*: E, WB, IH
Target: PLAUR
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 8B50
Application*: E, F, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D6
Application*: E, WB
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 13H210
Application*: IF
Target: PLAUR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBFYC-3037
Application*: WB, IC, P, C, E, IP, IF, F
Target: PLAUR
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 7J34
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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