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Mouse Anti-PLAUR Recombinant Antibody (CBT2333) (V2LY-0625-LY1039)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2333
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD87 (AA: 23-305) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
plasminogen activator, urokinase receptor
Entrez Gene ID
5329
UniProt ID
Q03405
Function
Acts as a receptor for urokinase plasminogen activator (PubMed:15677461).
Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Biological Process
Blood coagulation
Chemotaxis
Negative regulation of apoptotic process
Negative regulation of intrinsic apoptotic signaling pathway
Positive regulation of DNA binding
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of homotypic cell-cell adhesion
Positive regulation of protein phosphorylation
Positive regulation of release of cytochrome c from mitochondria
Regulation of cell adhesion
Regulation of fibrinolysis
Regulation of plasminogen activation
Regulation of proteolysis
Signal transduction
Urokinase plasminogen activator signaling pathway
Cellular Location
Cell membrane
Cell projection, invadopodium membrane
Note: Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
Isoform 1
Cell membrane
Isoform 2
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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