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Mouse Anti-PLAUR Recombinant Antibody (CBFYC-3037) (CBMAB-C3114-FY)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYC-3037
Antibody Isotype
IgG1, k
Application
WB, ICC, IHC-P, IHC-Fr, ELISA, IP, IF, FC

Basic Information

Immunogen
Plasminogen Activator, Urokinase Receptor
Specificity
Rat
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix.
Entrez Gene ID
50692
UniProt ID
P49616
Alternative Names
CD87; UPAR; URKR; U-PAR
Function
Acts as a receptor for urokinase plasminogen activator (PubMed:15677461).
Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Biological Process
Blood coagulation
Chemotaxis
Negative regulation of apoptotic process
Negative regulation of intrinsic apoptotic signaling pathway
Positive regulation of DNA binding
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of homotypic cell-cell adhesion
Positive regulation of protein phosphorylation
Positive regulation of release of cytochrome c from mitochondria
Regulation of cell adhesion
Regulation of fibrinolysis
Regulation of plasminogen activation
Regulation of proteolysis
Signal transduction
Urokinase plasminogen activator signaling pathway
Cellular Location
Cell membrane
Cell projection, invadopodium membrane
Note: Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
Isoform 1
Cell membrane
Isoform 2
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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