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Rat Anti-PLAUR Recombinant Antibody (10K37) (CBMAB-P2035-YC)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
10K37
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
NS0-derived, recombinant mouse uPAR (aa24-297
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 24-297

Target

Introduction
PLAUR (Plasminogen Activator, Urokinase Receptor) is a protein coding gene. Diseases associated with PLAUR include Ureter, Cancer Of and Perforated Corneal Ulcer. Among its related pathways are Cell adhesion_ECM remodeling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology annotations related to this gene include signaling receptor binding.
Entrez Gene ID
18793
UniProt ID
P35456
Alternative Names
UPAR; CD87; U-PAR; URKR
Function
Acts as a receptor for urokinase plasminogen activator (PubMed:15677461).
Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Biological Process
Blood coagulation
Chemotaxis
Negative regulation of apoptotic process
Negative regulation of intrinsic apoptotic signaling pathway
Positive regulation of DNA binding
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of homotypic cell-cell adhesion
Positive regulation of protein phosphorylation
Positive regulation of release of cytochrome c from mitochondria
Regulation of cell adhesion
Regulation of fibrinolysis
Regulation of plasminogen activation
Regulation of proteolysis
Signal transduction
Urokinase plasminogen activator signaling pathway
Cellular Location
Cell membrane
Cell projection, invadopodium membrane
Note: Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
Isoform 1
Cell membrane
Isoform 2
Secreted
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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