PLEKHA1

This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.

Full Name

pleckstrin homology domain containing A1

Alternative Names

TAPP1

Function

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.

Biological Process

Androgen metabolic processSource:Ensembl
B cell receptor signaling pathwaySource:UniProtKB1 publication
Cellular response to hydrogen peroxideSource:UniProtKB1 publication
Establishment of protein localizationSource:UniProtKB1 publication
Estrogen metabolic processSource:Ensembl
Face morphogenesisSource:Ensembl
Leydig cell differentiationSource:Ensembl
LuteinizationSource:Ensembl
Multicellular organism growthSource:Ensembl
Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionSource:UniProtKB1 publication
Phosphatidylinositol 3-kinase/protein kinase B signal transductionSource:UniProtKB1 publication
Platelet-derived growth factor receptor signaling pathwaySource:Ensembl
Post-embryonic developmentSource:Ensembl
Roof of mouth developmentSource:Ensembl
Ruffle organizationSource:UniProtKB1 publication
Skeletal system morphogenesisSource:Ensembl
Spermatogenesis

Cellular Location

Cytoplasm
Cell membrane
Nucleus
Note: Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.