POLR3E

POLR3E (RNA Polymerase III Subunit E) is a protein coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Pyrimidine metabolism (KEGG). Gene Ontology annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase III activity.

Full Name

polymerase (RNA) III (DNA directed) polypeptide E (80kD)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Biological Process

Defense response to virusIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Transcription, DNA-templatedIEA:InterPro

Cellular Location

Nucleus