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Mouse Anti-POLR3E Recombinant Antibody (2791C3a) (CBMAB-P2372-YC)

Provided herein is a Mouse monoclonal antibody against Human RNA Polymerase III Subunit E. The antibody can be used for immunoassay techniques, such as Dot, ICC.
See all POLR3E antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2791C3a
Antibody Isotype
IgG2b
Application
Dot, ICC

Basic Information

Immunogen
Recombinant human Polymerase (Rna) Iii (Dna Directed) Polypeptide E(83 d) (Polr3)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
Introduction
POLR3E (RNA Polymerase III Subunit E) is a protein coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Pyrimidine metabolism (KEGG). Gene Ontology annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase III activity.
Entrez Gene ID
55718
UniProt ID
Q9NVU0
Alternative Names
RPC5; SIN
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Biological Process
Defense response to virusIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Transcription, DNA-templatedIEA:InterPro
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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