PRDM14

PRDM14 is a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer.

Full Name

PR/SET Domain 14

Function

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity).
Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.

Biological Process

Cell fate specificationIEA:Ensembl
Cell morphogenesisIEA:Ensembl
Embryo implantationIEA:Ensembl
FertilizationIEA:Ensembl
Fibroblast growth factor receptor signaling pathwayIEA:Ensembl
Germ cell developmentIEA:Ensembl
Germ-line stem cell population maintenanceIEA:Ensembl
Histone H3-R26 methylationManual Assertion Based On ExperimentIBA:GO_Central
Homeostasis of number of cells within a tissueIEA:Ensembl
Inactivation of paternal X chromosomeIEA:Ensembl
Inner cell mass cell fate commitmentIEA:Ensembl
Negative regulation of fibroblast growth factor receptor signaling pathwayIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of flagellated sperm motilityIEA:Ensembl
Positive regulation of stem cell population maintenanceIEA:Ensembl
Regulation of DNA methylationIEA:Ensembl
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus