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PSMC5

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
Full Name
Proteasome 26S Subunit, ATPase 5
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Biological Process
Modulation of chemical synaptic transmissionIEA:Ensembl
Negative regulation of programmed cell death1 PublicationNAS:UniProtKB
Negative regulation of transcription, DNA-templatedIEA:Ensembl
Positive regulation of inclusion body assemblyIEA:Ensembl
Positive regulation of proteasomal protein catabolic process1 PublicationIC:UniProtKB
Positive regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:GO_Central
Cellular Location
Cytoplasm
Nucleus
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Anti-PSMC5 antibodies

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Mouse Anti-PSMC5 Recombinant Antibody (CBXS-4295) (CBMAB-S1541-CQ)

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Target: PSMC5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4295
Application*: WB, CI, IP
Datasheet SDS

Recombinant Mouse Anti-PSMC5 Recombinant Antibody (1B8) (CBMAB-XB0964-YC)

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Target: PSMC5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Human
Clone: 1B8
Application*: E, IF, IP, WB
Datasheet SDS

Rabbit Anti-PSMC5 Recombinant Antibody (CBYC-P709) (CBMAB-P3208-YC)

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Target: PSMC5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYC-P709
Application*: WB, IP, P, F, IC, IF
Datasheet SDS

Mouse Anti-PSMC5 Recombinant Antibody (35/p45) (CBMAB-P3207-YC)

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Target: PSMC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Rat
Clone: 35/p45
Application*: WB, IF
Datasheet SDS

Mouse Anti-PSMC5 Recombinant Antibody (25D5) (CBMAB-P3206-YC)

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Target: PSMC5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 25D5
Application*: WB
Datasheet SDS

Mouse Anti-PSMC5 Recombinant Antibody (p52(26S-17)) (CBMAB-2130CQ)

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Target: PSMC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Frog
Clone: p52(26S-17)
Application*: WB
Datasheet SDS

Mouse Anti-PSMC5 Recombinant Antibody (P45-110) (CBMAB-2129CQ)

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Target: PSMC5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: P45-110
Application*: P, IH, WB
Datasheet SDS

Mouse Anti-PSMC5 Recombinant Antibody (p32) (CBMAB-2125CQ)

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Target: PSMC5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: p32
Application*: WB, IF
Datasheet SDS

Mouse Anti-PSMC5 Recombinant Antibody (P27 (26S 104.75.1)) (CBMAB-2123CQ)

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Target: PSMC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Kangaroo
Clone: P27 (26S 104.75.1)
Application*: IF, WB
Datasheet SDS

Mouse Anti-PSMC5 Recombinant Antibody (CBLQP-002) (CBMAB-2066CQ)

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Target: PSMC5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Kangaroo
Clone: CBLQP-002
Application*: IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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