RAP2A

RAP2A (RAP2A, Member Of RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and ERK Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.

Full Name

RAP2A, Member Of RAS Oncogene Family

Function

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.

Biological Process

Biological Process actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of protein localizationManual Assertion Based On ExperimentIDA:MGI
Biological Process microvillus assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rap protein signal transductionISS:UniProtKB
Biological Process regulation of dendrite morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Recycling endosome membrane
Midbody
May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995).
Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443).

PTM

Ubiquitinated; undergoes 'Lys-63' monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A.
Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
(Microbial infection) Glucosylated at Thr-35 by C.difficile toxin TcdA in the colonic epithelium, and by P.sordellii toxin TcsL in the vascular endothelium.