Mouse Anti-RAP2A Recombinant Antibody (455410) (CBMAB-R1324-CN)

Name: Mouse Anti-RAP2A Recombinant Antibody (455410)
SKU: CBMAB-R1324-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

455410

Application

Immunogen

E. coli-derived recombinant human Rap2A/B, Met1-Gln183, Accession # P10114

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

LYOPH

Buffer

PBS, Trehalose

Concentration

LYOPH

More Infomation

Target

Full Name

RAP2A, Member Of RAS Oncogene Family

Introduction

RAP2A (RAP2A, Member Of RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and ERK Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.

Entrez Gene ID

Human	5911
Mouse	76108
Rat	114560

UniProt ID

Human	P10114
Mouse	Q80ZJ1
Rat	A0A0G2JTW1

Alternative Names

RAP2A, Member Of RAS Oncogene Family; RbBP-30; RAP2, Member Of RAS Oncogene Family (K-Rev); Ras-Related Protein Rap-2a; K-Rev; KREV; RAP2;

Function

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.

Biological Process

Biological Process actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of protein localizationManual Assertion Based On ExperimentIDA:MGI
Biological Process microvillus assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rap protein signal transductionISS:UniProtKB
Biological Process regulation of dendrite morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Recycling endosome membrane
Midbody
May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995).
Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443).

PTM

Ubiquitinated; undergoes 'Lys-63' monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A.
Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
(Microbial infection) Glucosylated at Thr-35 by C.difficile toxin TcdA in the colonic epithelium, and by P.sordellii toxin TcsL in the vascular endothelium.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-RAP2A Recombinant Antibody (12/Rap2) (CAT#: CBMAB-R1323-CN)

Mouse Anti-RAP2A Recombinant Antibody (C-2) (CAT#: CBMAB-R1325-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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