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Mouse Anti-RAP2A Recombinant Antibody (455410) (CBMAB-R1324-CN)

This product is a Mouse antibody that recognizes RAP2A. The antibody 455410 can be used for immunoassay techniques such as: WB.
See all RAP2A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
455410
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human Rap2A/B, Met1-Gln183, Accession # P10114
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, Trehalose
Concentration
LYOPH

Target

Full Name
RAP2A, Member Of RAS Oncogene Family
Introduction
RAP2A (RAP2A, Member Of RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and ERK Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.
Entrez Gene ID
Human5911
Mouse76108
Rat114560
UniProt ID
HumanP10114
MouseQ80ZJ1
RatA0A0G2JTW1
Alternative Names
RAP2A, Member Of RAS Oncogene Family; RbBP-30; RAP2, Member Of RAS Oncogene Family (K-Rev); Ras-Related Protein Rap-2a; K-Rev; KREV; RAP2;
Function
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
Biological Process
Biological Process actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process establishment of protein localizationManual Assertion Based On ExperimentIDA:MGI
Biological Process microvillus assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Rap protein signal transductionISS:UniProtKB
Biological Process regulation of dendrite morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Recycling endosome membrane
Midbody
May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995).
Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443).
PTM
Ubiquitinated; undergoes 'Lys-63' monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A.
Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
(Microbial infection) Glucosylated at Thr-35 by C.difficile toxin TcdA in the colonic epithelium, and by P.sordellii toxin TcsL in the vascular endothelium.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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