RASD2
This gene encodes a Ras-related protein that enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades. [provided by RefSeq]
Full Name
RASD family, member 2
Function
GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
Biological Process
Biological Process locomotory behaviorISS:UniProtKB
Biological Process positive regulation of protein kinase B signalingISS:UniProtKB
Biological Process positive regulation of protein sumoylationISS:UniProtKB
Biological Process regulation of cAMP-mediated signalingISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic transmission, dopaminergicIEA:Ensembl
Biological Process positive regulation of protein kinase B signalingISS:UniProtKB
Biological Process positive regulation of protein sumoylationISS:UniProtKB
Biological Process regulation of cAMP-mediated signalingISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic transmission, dopaminergicIEA:Ensembl
Cellular Location
Cell membrane
PTM
Farnesylated. Farnesylation is required for membrane targeting (By similarity).
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Anti-RASD2 antibodies
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Target: RASD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2G8
Application*: WB, IF, F
Target: RASD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1H10
Application*: WB, IF, F
Target: RASD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G8
Application*: WB, F
Target: RASD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Dog, Human
Clone: 1G1
Application*: WB, F
Target: RASD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F7
Application*: WB, IH, IF, F
Target: RASD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D11
Application*: WB, F
Target: RASD2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1C7
Application*: E, IP, WB
Target: RASD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: 1A12
Application*: WB, IF, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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