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Mouse Anti-RASD2 Recombinant Antibody (1C7) (CBMAB-R1472-CN)

This product is a Mouse antibody that recognizes RASD2. The antibody 1C7 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all RASD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C7
Antibody Isotype
IgG2b, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
Full-length recombinant corresponding to aa. 1-267 from RASD2 (H13419) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RASD family, member 2
Introduction
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
Entrez Gene ID
23551
UniProt ID
Q96D21
Alternative Names
RASD Family Member 2; Ras Homolog Enriched In Striatum; Tumor Endothelial Marker 2; TEM2; GTP-Binding Protein Rhes; RASD Family, Member 2; MGC:4834; Rhes;
Function
GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
Biological Process
Biological Process locomotory behaviorISS:UniProtKB
Biological Process positive regulation of protein kinase B signalingISS:UniProtKB
Biological Process positive regulation of protein sumoylationISS:UniProtKB
Biological Process regulation of cAMP-mediated signalingISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic transmission, dopaminergicIEA:Ensembl
Cellular Location
Cell membrane
PTM
Farnesylated. Farnesylation is required for membrane targeting (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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