RB1CC1

The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

Full Name

RB1 Inducible Coiled-Coil 1

Function

Involved in autophagy (PubMed:21775823).
Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225).
Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity).
Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity).
Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124).
Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity).
Functions as a DNA-binding transcription factor (PubMed:12095676).
Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007).
Plays a crucial role in muscular differentiation (PubMed:12163359).
Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).

Biological Process

Biological Process autophagosome assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process autophagyISS:GO_Central
Biological Process autophagy of mitochondrionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process autophagy of peroxisomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process extrinsic apoptotic signaling pathwayIEA:Ensembl
Biological Process glycophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heart developmentIEA:Ensembl
Biological Process liver developmentIEA:Ensembl
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process negative regulation of extrinsic apoptotic signaling pathwayIEA:Ensembl
Biological Process piecemeal microautophagy of the nucleusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of autophagyIEA:Ensembl
Biological Process positive regulation of cell sizeIEA:Ensembl
Biological Process positive regulation of JNK cascadeIEA:Ensembl
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process protein phosphorylationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of protein lipidationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process reticulophagyManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Cytoplasm
Cytoplasm, cytosol
Preautophagosomal structure
Lysosome
Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.