REC8

This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

REC8 Meiotic Recombination Protein

Function

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).

Biological Process

Biological Process double-strand break repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process double-strand break repair via homologous recombinationIEA:Ensembl
Biological Process fertilizationIEA:Ensembl
Biological Process male meiosis IIEA:Ensembl
Biological Process meiotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Biological Process meiotic sister chromatid cohesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process oocyte maturationIEA:Ensembl
Biological Process reciprocal meiotic recombinationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process seminiferous tubule developmentIEA:Ensembl
Biological Process sister chromatid cohesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatid developmentIEA:Ensembl
Biological Process spermatogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptonemal complex assemblyIEA:Ensembl

Cellular Location

Nucleus
Chromosome
Chromosome, centromere
In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. Localized to centromeres and spindle poles in endopolyploid tumor cells.

PTM

Phosphorylated.