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Mouse Anti-REC8 Recombinant Antibody (2G3) (CBMAB-R2001-CN)

This product is a Mouse antibody that recognizes REC8. The antibody 2G3 can be used for immunoassay techniques such as: ELISA.
See all REC8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G3
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa. 1-110 from REC8L1 (H04159) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
REC8 Meiotic Recombination Protein
Introduction
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
9985
UniProt ID
O95072
Alternative Names
REC8 Meiotic Recombination Protein; Cohesin Rec8p; REC8L1; Meiotic Recombination And Sister Chromatid Cohesion Phosphoprotein Of The Rad21p Family; Recombination And Sister Chromatid Cohesion Protein Homolog; Meiotic Recombination Protein REC8 Homolog; Meiotic Recombination Protein REC8-Like 1; Human Homolog Of Rad21, S. Pombe; REC8 Homolog (Yeast);
Function
Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).
Biological Process
Biological Process double-strand break repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process double-strand break repair via homologous recombinationIEA:Ensembl
Biological Process fertilizationIEA:Ensembl
Biological Process male meiosis IIEA:Ensembl
Biological Process meiotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Biological Process meiotic sister chromatid cohesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process oocyte maturationIEA:Ensembl
Biological Process reciprocal meiotic recombinationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process seminiferous tubule developmentIEA:Ensembl
Biological Process sister chromatid cohesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatid developmentIEA:Ensembl
Biological Process spermatogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptonemal complex assemblyIEA:Ensembl
Cellular Location
Nucleus
Chromosome
Chromosome, centromere
In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. Localized to centromeres and spindle poles in endopolyploid tumor cells.
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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