REEP5
REEP5 (Receptor Accessory Protein 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. An important paralog of this gene is REEP6.
Full Name
Receptor Accessory Protein 5
Function
Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.
Biological Process
Biological Process endoplasmic reticulum membrane organizationISS:UniProtKB
Biological Process endoplasmic reticulum organizationISS:FlyBase
Biological Process regulation of intracellular transportISS:FlyBase
Biological Process endoplasmic reticulum organizationISS:FlyBase
Biological Process regulation of intracellular transportISS:FlyBase
Cellular Location
Endoplasmic reticulum membrane
Sarcoplasmic reticulum membrane
Localizes to endoplasmic reticulum tubular network (PubMed:23969831).
In cardiomyocytes, localizes to the junctional sarcoplasmic reticulum membrane which is closely tethered to the cell membrane and contractile machinery (By similarity).
Sarcoplasmic reticulum membrane
Localizes to endoplasmic reticulum tubular network (PubMed:23969831).
In cardiomyocytes, localizes to the junctional sarcoplasmic reticulum membrane which is closely tethered to the cell membrane and contractile machinery (By similarity).
Topology
Cytoplasmic: 1-34
Helical: 35-51
Lumenal: 52-53
Helical: 54-74
Cytoplasmic: 75-84
Helical: 85-103
Lumenal: 104-105
Helical: 106-123
Cytoplasmic: 124-189
Helical: 35-51
Lumenal: 52-53
Helical: 54-74
Cytoplasmic: 75-84
Helical: 85-103
Lumenal: 104-105
Helical: 106-123
Cytoplasmic: 124-189
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Anti-REEP5 antibodies
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Target: REEP5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G11
Application*: WB, E
Target: REEP5
Host: Mouse
Specificity: Human
Clone: F-2
Application*: WB, IP, IF, E
Target: REEP5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Frog
Clone: CBCNR-378
Application*: WB, E, IF
Target: REEP5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4D2
Application*: WB, IH, F
Target: REEP5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G11
Application*: E, WB
Target: REEP5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0092
Application*: WB
Target: REEP5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0011
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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