RNF5

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

Full Name

Ring Finger Protein 5

Function

Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19285439, PubMed:19269966).
May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381).
Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019).
Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924).
Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966).
Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439).
Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945).

Biological Process

Biological Process endoplasmic reticulum mannose trimmingTAS:Reactome
Biological Process ER-associated misfolded protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ERAD pathwayManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process negative regulation of autophagyIEA:Ensembl
Biological Process protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein destabilizationIEA:Ensembl
Biological Process protein K48-linked ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein K63-linked ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of autophagosome assemblyIEA:Ensembl
Biological Process response to bacteriumIEA:Ensembl
Biological Process transmembrane transportTAS:Reactome
Biological Process ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Mitochondrion membrane
Endoplasmic reticulum membrane
Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.