RNH1
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Full Name
Ribonuclease/Angiogenin Inhibitor 1
Function
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
Biological Process
Biological Process mRNA catabolic process1 PublicationNAS:UniProtKB
Biological Process regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
PTM
The N-terminus is blocked.
At least 30 of the 32 cysteine residues are in the reduced form.
At least 30 of the 32 cysteine residues are in the reduced form.
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Anti-RNH1 antibodies
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CompareTarget: RNH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF372
Application*: ELISA, WB
Target: RNH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey, Rat
Clone: 3F11
Application*: F, WB
Target: RNH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: 1H23
Application*: WB, E
Target: RNH1
Specificity: Human
Target: RNH1
Host: Mouse
Specificity: Human
Clone: PAT1H23AT
Application*: E, WB
Target: RNH1
Host: Mouse
Specificity: Mouse, Rat
Clone: D-3
Application*: WB, IP, IF, E
Target: RNH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBCNR-630
Application*: E, WB, P
Target: RNH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNR-628
Application*: E, WB
Target: RNH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBCNR-492
Application*: WB, E, F
Target: RNH1
Host: Mouse
Specificity: Mouse
Clone: C-1
Application*: WB, IP, IF, E
Target: RNH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: AT1H23
Application*: E, WB
Target: RNH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 5D10
Application*: E, WB
Target: RNH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4G4
Application*: F, IF, WB
Target: RNH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4A1C4
Application*: E, WB
Target: RNH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3F5
Application*: E, WB
Target: RNH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B1
Application*: WB, IH
Target: RNH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B7
Application*: F, IF, IH, WB
Target: RNH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 10C309
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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