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RNH1

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

Full Name

Ribonuclease/Angiogenin Inhibitor 1

Function

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Biological Process

Biological Process mRNA catabolic process1 PublicationNAS:UniProtKB
Biological Process regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm

PTM

The N-terminus is blocked.
At least 30 of the 32 cysteine residues are in the reduced form.

Anti-RNH1 antibodies

Mouse Anti-RNH1 Recombinant Antibody (CF372) (CBMAB-FT132LY)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CF372

Application*: ELISA, WB

Mouse Anti-RNH1 Recombinant Antibody (PAT1H23AT) (CBMAB-R3070-CN)

SDS

Target: RNH1

Host: Mouse

Specificity: Human

Clone: PAT1H23AT

Application*: E, WB

Mouse Anti-RNH1 Recombinant Antibody (D-3) (CBMAB-R3069-CN)

SDS

Target: RNH1

Host: Mouse

Specificity: Mouse, Rat

Clone: D-3

Application*: WB, IP, IF, E

Mouse Anti-RNH1 Recombinant Antibody (CBCNR-630) (CBMAB-R3068-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: CBCNR-630

Application*: E, WB, P

Mouse Anti-RNH1 Recombinant Antibody (CBCNR-628) (CBMAB-R3066-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBCNR-628

Application*: E, WB

Mouse Anti-RNH1 Recombinant Antibody (CBCNR-492) (CBMAB-R3065-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBCNR-492

Application*: WB, E, F

Mouse Anti-RNH1 Recombinant Antibody (C-1) (CBMAB-R3064-CN)

SDS

Target: RNH1

Host: Mouse

Specificity: Mouse

Clone: C-1

Application*: WB, IP, IF, E

Mouse Anti-RNH1 Recombinant Antibody (AT1H23) (CBMAB-R3063-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: AT1H23

Application*: E, WB

Mouse Anti-RNH1 Recombinant Antibody (5D10) (CBMAB-R3062-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Rat

Clone: 5D10

Application*: E, WB

Mouse Anti-RNH1 Recombinant Antibody (4G4) (CBMAB-R3061-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4G4

Application*: F, IF, WB

Mouse Anti-RNH1 Recombinant Antibody (4A1C4) (CBMAB-R3060-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4A1C4

Application*: E, WB

Mouse Anti-RNH1 Recombinant Antibody (3F5) (CBMAB-R3059-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3F5

Application*: E, WB

Mouse Anti-RNH1 Recombinant Antibody (3F11) (CBMAB-R3058-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Monkey, Rat

Clone: 3F11

Application*: F, WB

Mouse Anti-RNH1 Recombinant Antibody (2B1) (CBMAB-R3057-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2B1

Application*: WB, IH

Mouse Anti-RNH1 Recombinant Antibody (1B7) (CBMAB-R3056-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1B7

Application*: F, IF, IH, WB

Mouse Anti-RNH1 Recombinant Antibody (10C309) (CBMAB-R3055-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: 10C309

Application*: E, WB

Mouse Anti-RNH1 Recombinant Antibody (1H23) (CBMAB-R0298-CN)

SDS

Target: RNH1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Mouse, Human

Clone: 1H23

Application*: WB, E

RNH1 Matched Antibody Pair (1011) (APMAB-1011LY)

SDS

Target: RNH1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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