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Mouse Anti-RNH1 Recombinant Antibody (4G4) (CBMAB-R3061-CN)

This product is a Mouse antibody that recognizes RNH1. The antibody 4G4 can be used for immunoassay techniques such as: FC, IF, WB.
See all RNH1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G4
Antibody Isotype
IgG1
Application
FC, IF, WB

Basic Information

Immunogen
Full length human recombinant protein of human RNH1 (NP_002930) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide

Target

Full Name
Ribonuclease/Angiogenin Inhibitor 1
Introduction
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo. [supplied by OMIM, Jul 2010]
Entrez Gene ID
6050
UniProt ID
P13489
Alternative Names
Ribonuclease/Angiogenin Inhibitor 1; Placental Ribonuclease Inhibitor; Placental RNase Inhibitor; RAI; RNH; Ribonuclease/Angiogenin Inhibitor; Testicular Tissue Protein Li 164; Ribonuclease Inhibitor; PRI;
Function
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
Biological Process
Biological Process mRNA catabolic process1 PublicationNAS:UniProtKB
Biological Process regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
PTM
The N-terminus is blocked.
At least 30 of the 32 cysteine residues are in the reduced form.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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