Mouse Anti-RNH1 Recombinant Antibody (1B7) (CBMAB-R3056-CN)

Name: Mouse Anti-RNH1 Recombinant Antibody (1B7)
SKU: CBMAB-R3056-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

1B7

Application

FC, IF, IHC, WB

Immunogen

A full length recombinant protein of human RNH1 (NP_002930) produced in HEK293T cells

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.5-1 mg/mL

More Infomation

Target

Full Name

Ribonuclease/Angiogenin Inhibitor 1

Introduction

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo. [supplied by OMIM, Jul 2010]

Entrez Gene ID

6050

UniProt ID

P13489

Alternative Names

Ribonuclease/Angiogenin Inhibitor 1; Placental Ribonuclease Inhibitor; Placental RNase Inhibitor; RAI; RNH; Ribonuclease/Angiogenin Inhibitor; Testicular Tissue Protein Li 164; Ribonuclease Inhibitor; PRI;

Function

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Biological Process

Biological Process mRNA catabolic process1 PublicationNAS:UniProtKB
Biological Process regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm

PTM

The N-terminus is blocked.
At least 30 of the 32 cysteine residues are in the reduced form.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

RNH1 Matched Antibody Pair (1011) (CAT#: APMAB-1011LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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