RPL10

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq]

Full Name

ribosomal protein L10

Function

Component of the large ribosomal subunit (PubMed:26290468).
Plays a role in the formation of actively translating ribosomes (PubMed:26290468).
May play a role in the embryonic brain development (PubMed:25316788).

Biological Process

Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process embryonic brain developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:CAFA
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:CAFA
Biological Process regulation of translationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ribosomal large subunit assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process translation1 PublicationNAS:UniProtKB

Cellular Location

cytosol
cytosolic large ribosomal subunit
cytosolic ribosome
endoplasmic reticulum
membrane
nucleus
protein-containing complex
smooth endoplasmic reticulum
synapse

Involvement in disease

Autism, X-linked 5 (AUTSX5):
A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate intellectual disability.
Intellectual developmental disorder, X-linked, syndromic 35 (MRXS35):
A syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features.

PTM

Citrullinated by PADI4.
Ufmylated by UFL1.