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Mouse Anti-RPL10 Recombinant Antibody (9A8) (CBMAB-R3343-CN)

This product is a Mouse antibody that recognizes RPL10. The antibody 9A8 can be used for immunoassay techniques such as: WB, IHC.
See all RPL10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
9A8
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human RPL10 (NP_006004) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
ribosomal protein L10
Introduction
This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Entrez Gene ID
6134
UniProt ID
P27635
Alternative Names
Ribosomal Protein L10; Large Ribosomal Subunit Protein UL16; Laminin Receptor Homolog; Tumor Suppressor QM; DXS648E; QM; Wilms Tumor-Related Protein; 0S Ribosomal Protein L10;
Function
Component of the large ribosomal subunit (PubMed:26290468).
Plays a role in the formation of actively translating ribosomes (PubMed:26290468).
May play a role in the embryonic brain development (PubMed:25316788).
Biological Process
Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process embryonic brain developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:CAFA
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:CAFA
Biological Process regulation of translationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ribosomal large subunit assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process translation1 PublicationNAS:UniProtKB
Cellular Location
cytosol
cytosolic large ribosomal subunit
cytosolic ribosome
endoplasmic reticulum
membrane
nucleus
protein-containing complex
smooth endoplasmic reticulum
synapse
Involvement in disease
Autism, X-linked 5 (AUTSX5):
A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate intellectual disability.
Intellectual developmental disorder, X-linked, syndromic 35 (MRXS35):
A syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features.
PTM
Citrullinated by PADI4.
Ufmylated by UFL1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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