RRAGB

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Full Name

Ras Related GTP Binding B

Function

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:18497260, PubMed:20381137, PubMed:24095279, PubMed:23723238).
Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form (PubMed:18497260, PubMed:20381137, PubMed:24095279, PubMed:23723238).
In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:18497260, PubMed:20381137, PubMed:23723238).
Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008).

Biological Process

Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to leucine starvationManual Assertion Based On ExperimentIMP:CAFA
Biological Process cellular response to starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of autophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of TOR signalingManual Assertion Based On ExperimentIGI:UniProtKB

Cellular Location

Cytoplasm
Lysosome