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Rabbit Anti-RRAGB Recombinant Antibody (D18F3) (CBMAB-R3636-CN)

This product is a Rabbit antibody that recognizes RRAGB. The antibody D18F3 can be used for immunoassay techniques such as: WB, IP.
See all RRAGB antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D18F3
Application
WB, IP

Basic Information

Specificity
Human, Monkey
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ras Related GTP Binding B
Introduction
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human10325
Monkey704260
UniProt ID
HumanQ5VZM2
MonkeyF7D021
Alternative Names
Ras Related GTP Binding B; Rag B; RAGB; Ras-Related GTP-Binding Protein B; Ras-Related GTP Binding B; GTP-Binding Protein RagB; BA465E19.1;
Function
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:18497260, PubMed:20381137, PubMed:24095279, PubMed:23723238).
Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form (PubMed:18497260, PubMed:20381137, PubMed:24095279, PubMed:23723238).
In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:18497260, PubMed:20381137, PubMed:23723238).
Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008).
Biological Process
Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to leucine starvationManual Assertion Based On ExperimentIMP:CAFA
Biological Process cellular response to starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of autophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of TOR signalingManual Assertion Based On ExperimentIGI:UniProtKB
Cellular Location
Cytoplasm
Lysosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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