Rabbit Anti-RRAGB Recombinant Antibody (D18F3) (CBMAB-R3636-CN)

Name: Rabbit Anti-RRAGB Recombinant Antibody (D18F3)
SKU: CBMAB-R3636-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

D18F3

Application

WB, IP

Specificity

Human, Monkey

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

Ras Related GTP Binding B

Introduction

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	10325
Monkey	704260

UniProt ID

Human	Q5VZM2
Monkey	F7D021

Alternative Names

Ras Related GTP Binding B; Rag B; RAGB; Ras-Related GTP-Binding Protein B; Ras-Related GTP Binding B; GTP-Binding Protein RagB; BA465E19.1;

Function

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:18497260, PubMed:20381137, PubMed:24095279, PubMed:23723238).
Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form (PubMed:18497260, PubMed:20381137, PubMed:24095279, PubMed:23723238).
In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:18497260, PubMed:20381137, PubMed:23723238).
Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008).

Biological Process

Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process cellular response to amino acid stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to leucine starvationManual Assertion Based On ExperimentIMP:CAFA
Biological Process cellular response to starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of autophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of TOR signalingManual Assertion Based On ExperimentIGI:UniProtKB

Cellular Location

Cytoplasm
Lysosome

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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