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RRAS

The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]
Full Name
RAS Related
Function
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267).
With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).
Biological Process
Biological Process face morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process leukocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of Schwann cell migrationIEA:Ensembl
Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of endothelial cell-matrix adhesion via fibronectinManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of vasculogenesisManual Assertion Based On ExperimentIMP:CACAO
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Schwann cell migrationIEA:Ensembl
Cellular Location
Cell membrane
Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
PTM
S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability.

Anti-RRAS antibodies

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Target: RRAS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E12
Application*: E, IP, WB
Target: RRAS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBCNR-797
Application*: IP, E, WB
Target: RRAS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBCNR-798
Application*: WB
Target: RRAS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBCNR-799
Application*: WB, P
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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