RRAS

The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]

Full Name

RAS Related

Function

Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267).
With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).

Biological Process

Biological Process face morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process leukocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of Schwann cell migrationIEA:Ensembl
Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of endothelial cell-matrix adhesion via fibronectinManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of vasculogenesisManual Assertion Based On ExperimentIMP:CACAO
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Schwann cell migrationIEA:Ensembl

Cellular Location

Cell membrane
Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

PTM

S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability.