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Mouse Anti-RRAS Recombinant Antibody (2E12) (CBMAB-R3643-CN)

This product is a Mouse antibody that recognizes RRAS. The antibody 2E12 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all RRAS antibodies
Published Data
Fig.1 Western blot analysis of endogenous R-Ras in 11 human breast cancer cell lines and one normal human breast epithelial cell line.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E12
Antibody Isotype
IgG2b, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 109-218 from human RRAS (H16286a) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAS Related
Introduction
The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]
Entrez Gene ID
6237
UniProt ID
P10301
Alternative Names
RAS Related; Related RAS Viral (R-Ras) Oncogene Homolog; Oncogene RRAS; P23; Ras Family Small GTP Binding Protein R-Ras; Ras-Related Protein R-Ras; R-Ras;
Function
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267).
With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).
Biological Process
Biological Process face morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process leukocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of Schwann cell migrationIEA:Ensembl
Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of endothelial cell-matrix adhesion via fibronectinManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of vasculogenesisManual Assertion Based On ExperimentIMP:CACAO
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Schwann cell migrationIEA:Ensembl
Cellular Location
Cell membrane
Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
PTM
S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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