SARS-CoV N

The SARS coronavirus, sometimes shortened to SARS-CoV, is the virus that causes severe acute respiratory syndrome (SARS). SARS coronavirus is a positive and single stranded RNA virus belonging to a family of enveloped coronaviruses. Its genome is about 29.7kb, which is one of the largest among RNA viruses. The SARS virus has 13 known genes and 14 known proteins. There are 265 nucleotides in the 5'UTR and 342 nucleotides in the 3'UTR. SARS is similar to other coronaviruses in that its genome expression starts with translation of two large ORFs, 1a and 1b, both of which are polyproteins. The functions of several of these proteins are known: ORFs 1a and 1b encode the replicase and there are four major structural proteins: nucleocapsid, spike, membrane and envelope. It also encodes for eight unique proteins, known as the accessory proteins, all with no known homologues. Nucleocapsid proteins of other coronavirus have been reported to be involved in forming the viral core and also in the packaging and transcription of the viral RNA.
Full Name
SARS coronavirus nucleocapsid protein
Function
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170).
May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455).
Biological Process
Viral RNA genome packaging
Cellular Location
Virion
Host endoplasmic reticulum-Golgi intermediate compartment
Host Golgi apparatus
Host cytoplasm, host perinuclear region
Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
PTM
ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.
Phosphorylated on serine and threonine residues (By similarity).
Phosphorylated by host GSK3A and GSK3B. Phosphorylation allows recruitment of host RNA helicase DDX1 which facilitates template readthrough and enables longer subgenomic mRNA synthesis
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Anti-SARS-CoV N antibodies

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Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0409) (CBMAB-V208-0443-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG2b
Specificity: SARS
Clone: CBMJV-0409
Application*: WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0586) (CBMAB-V208-0670-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgM
Specificity: SARS
Clone: CBMJV-0586
Application*: WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0502) (CBMAB-V208-0575-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG2b
Specificity: SARS
Clone: CBMJV-0502
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (KT3) (CBMAB-V208-0554-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG2b
Specificity: SARS
Clone: KT3
Application*: E, WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (IFR0111) (CBMAB-V208-0553-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG1
Specificity: SARS
Clone: IFR0111
Application*: E, WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0432) (CBMAB-V208-0470-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG1
Specificity: SARS
Clone: CBMJV-0432
Application*: WB, IF
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0429) (CBMAB-V208-0465-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG2a
Specificity: SARS
Clone: CBMJV-0429
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0418) (CBMAB-V208-0453-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG1
Specificity: SARS
Clone: CBMJV-0418
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0417) (CBMAB-V208-0452-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG2b
Specificity: SARS
Clone: CBMJV-0417
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0382) (CBMAB-V208-0401-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG2a
Specificity: SARS
Clone: CBMJV-0382
Application*: E
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0249) (CBMAB-V208-0265-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG2b
Specificity: SARS
Clone: CBMJV-0249
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0114) (CBMAB-V208-0117-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG2a
Specificity: SARS
Clone: CBMJV-0114
Application*: E, WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0113) (CBMAB-V208-0116-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG1
Specificity: SARS
Clone: CBMJV-0113
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0112) (CBMAB-V208-0115-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG1
Specificity: SARS
Clone: CBMJV-0112
Application*: E, WB
Datasheet SDS

Mouse Anti-SARS-CoV N Recombinant Antibody (CBMJV-0111) (CBMAB-V208-0114-WJ)

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Target: SARS-CoV N
Host: Mouse
Antibody Isotype: IgG1
Specificity: SARS
Clone: CBMJV-0111
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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