SDR16C5

This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants.

Full Name

Short Chain Dehydrogenase/Reductase Family 16C Member 5

Function

Oxidoreductase with strong preference for NAD (PubMed:18926804).
Active in both the oxidative and reductive directions (PubMed:18926804).
Oxidizes all-trans-retinol in all-trans-retinaldehyde (PubMed:18926804).
No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD+/NADH or NADP+/NADPH (PubMed:18926804).

Biological Process

Biological Process keratinocyte proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of histone acetylationManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of histone deacetylationManual Assertion Based On ExperimentIDA:CAFA
Biological Process retinal metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retinol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Endoplasmic reticulum membrane