Sign in or Register   Sign in or Register
  |  

Mouse Anti-SDR16C5 Recombinant Antibody (CBXS-3121) (CBMAB-S5865-CQ)

This product is a mouse antibody that recognizes SDR16C5. The antibody CBXS-3121 can be used for immunoassay techniques such as: ELISA, WB.
See all SDR16C5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXS-3121
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant protein corresponding to aa26-310 from human RDHE2 (AAH37219) with GST tag
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Short Chain Dehydrogenase/Reductase Family 16C Member 5
Introduction
This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human195814
Mouse242285
Rat297805
UniProt ID
HumanQ8N3Y7
MouseQ7TQA3
RatD3ZS85
Alternative Names
Short Chain Dehydrogenase/Reductase Family 16C Member 5; Retinal Short-Chain Dehydrogenase Reductase 2; Epidermal Retinol Dehydrogenase 2; RETSDR2; RDH-E2; EPHD-2; RDHE2;
Function
Oxidoreductase with strong preference for NAD (PubMed:18926804).
Active in both the oxidative and reductive directions (PubMed:18926804).
Oxidizes all-trans-retinol in all-trans-retinaldehyde (PubMed:18926804).
No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD+/NADH or NADP+/NADPH (PubMed:18926804).
Biological Process
Biological Process keratinocyte proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of histone acetylationManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of histone deacetylationManual Assertion Based On ExperimentIDA:CAFA
Biological Process retinal metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retinol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SDR16C5 Recombinant Antibody (CBXS-3121)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare