Mouse Anti-SDR16C5 Recombinant Antibody (CBXS-3121) (CBMAB-S5865-CQ)

Name: Mouse Anti-SDR16C5 Recombinant Antibody (CBXS-3121)
SKU: CBMAB-S5865-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-3121

Application

ELISA, WB

Immunogen

Full length recombinant protein corresponding to aa26-310 from human RDHE2 (AAH37219) with GST tag

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Short Chain Dehydrogenase/Reductase Family 16C Member 5

Introduction

This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	195814
Mouse	242285
Rat	297805

UniProt ID

Human	Q8N3Y7
Mouse	Q7TQA3
Rat	D3ZS85

Alternative Names

Short Chain Dehydrogenase/Reductase Family 16C Member 5; Retinal Short-Chain Dehydrogenase Reductase 2; Epidermal Retinol Dehydrogenase 2; RETSDR2; RDH-E2; EPHD-2; RDHE2;

Function

Oxidoreductase with strong preference for NAD (PubMed:18926804).
Active in both the oxidative and reductive directions (PubMed:18926804).
Oxidizes all-trans-retinol in all-trans-retinaldehyde (PubMed:18926804).
No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD+/NADH or NADP+/NADPH (PubMed:18926804).

Biological Process

Biological Process keratinocyte proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of histone acetylationManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of histone deacetylationManual Assertion Based On ExperimentIDA:CAFA
Biological Process retinal metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retinol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Endoplasmic reticulum membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-SDR16C5 Recombinant Antibody (3G8) (CAT#: CBMAB-A7504-LY)

Isotype control

For research use only. Not intended for any clinical use.

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