SEMA5A

This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.

Full Name

Semaphorin 5A

Function

Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity).
Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.

Biological Process

Biological Process axon extensionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process axonal fasciculationISS:UniProtKB
Biological Process blood vessel endothelial cell proliferation involved in sprouting angiogenesisISS:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cell chemotaxisISS:UniProtKB
Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process diencephalon developmentISS:UniProtKB
Biological Process negative regulation of axon extension involved in axon guidanceISS:UniProtKB
Biological Process negative regulation of cell adhesionISS:UniProtKB
Biological Process negative regulation of endothelial cell apoptotic processISS:UniProtKB
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive chemotaxisISS:UniProtKB
Biological Process positive regulation of actin filament depolymerizationISS:UniProtKB
Biological Process positive regulation of angiogenesisISS:UniProtKB
Biological Process positive regulation of axon extension involved in axon guidanceISS:UniProtKB
Biological Process positive regulation of canonical Wnt signaling pathwayISS:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of endothelial cell chemotaxisISS:UniProtKB
Biological Process positive regulation of endothelial cell proliferationISS:UniProtKB
Biological Process positive regulation of protein kinase B signalingISS:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal clusteringISS:UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 23-968
Helical: 969-989
Cytoplasmic: 990-1074