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Mouse Anti-SEMA5A Recombinant Antibody (CBXS-1977) (CBMAB-S4748-CQ)

This product is a mouse antibody that recognizes SEMA5A. The antibody CBXS-1977 can be used for immunoassay techniques such as: IHC.
See all SEMA5A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1977
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human Semaphorin 5A, Glu23-Thr765, Accession # Q13591
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Semaphorin 5A
Introduction
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.
Entrez Gene ID
9037
UniProt ID
Q13591
Alternative Names
Semaphorin 5A; Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type 1-Like), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 5A; Sema F; SEMAF; Semaphorin-5A; Semaphorin F; Semaphorin-F; SemF;
Function
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity).
Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Biological Process
Biological Process axon extensionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process axonal fasciculationISS:UniProtKB
Biological Process blood vessel endothelial cell proliferation involved in sprouting angiogenesisISS:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cell chemotaxisISS:UniProtKB
Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process diencephalon developmentISS:UniProtKB
Biological Process negative regulation of axon extension involved in axon guidanceISS:UniProtKB
Biological Process negative regulation of cell adhesionISS:UniProtKB
Biological Process negative regulation of endothelial cell apoptotic processISS:UniProtKB
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive chemotaxisISS:UniProtKB
Biological Process positive regulation of actin filament depolymerizationISS:UniProtKB
Biological Process positive regulation of angiogenesisISS:UniProtKB
Biological Process positive regulation of axon extension involved in axon guidanceISS:UniProtKB
Biological Process positive regulation of canonical Wnt signaling pathwayISS:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of endothelial cell chemotaxisISS:UniProtKB
Biological Process positive regulation of endothelial cell proliferationISS:UniProtKB
Biological Process positive regulation of protein kinase B signalingISS:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal clusteringISS:UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 23-968
Helical: 969-989
Cytoplasmic: 990-1074
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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