SHB

Domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene.

Full Name

Src homology 2 domain containing adaptor protein B

Function

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Biological Process

Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process B cell proliferationIEA:Ensembl
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process hematopoietic stem cell proliferationIEA:Ensembl
Biological Process negative regulation of oocyte maturationIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process positive regulation of mitotic cell cycleIEA:Ensembl
Biological Process positive regulation of T-helper cell differentiationIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process T cell receptor signaling pathwayIEA:Ensembl

Cellular Location

Cytoplasm
Cell membrane
Associates with membrane lipid rafts upon TCR stimulation.

PTM

Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.