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Mouse Anti-SHB Recombinant Antibody (4C11) (CBMAB-A8106-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
4C11
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SHB (NP_003019.2, 348 a.a. ~ 446 a.a) partial recombinant protein with GST-pstS1 tag.
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Src homology 2 domain containing adaptor protein B
Entrez Gene ID
Human6461
Rat362513
UniProt ID
HumanQ15464
RatD3ZN31
Alternative Names
RP11-3J10.8; bA3J10.2
Function
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Biological Process
Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process B cell proliferationIEA:Ensembl
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process hematopoietic stem cell proliferationIEA:Ensembl
Biological Process negative regulation of oocyte maturationIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process positive regulation of mitotic cell cycleIEA:Ensembl
Biological Process positive regulation of T-helper cell differentiationIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process T cell receptor signaling pathwayIEA:Ensembl
Cellular Location
Cytoplasm
Cell membrane
Associates with membrane lipid rafts upon TCR stimulation.
PTM
Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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