Mouse Anti-SHB Recombinant Antibody (4C11) (CBMAB-A8106-LY)

Name: Mouse Anti-SHB Recombinant Antibody (4C11)
SKU: CBMAB-A8106-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4C11

Application

WB, ELISA

Immunogen

SHB (NP_003019.2, 348 a.a. ~ 446 a.a) partial recombinant protein with GST-pstS1 tag.

Specificity

Human, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Src homology 2 domain containing adaptor protein B

Entrez Gene ID

Human	6461
Rat	362513

UniProt ID

Human	Q15464
Rat	D3ZN31

Alternative Names

RP11-3J10.8; bA3J10.2

Function

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Biological Process

Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process B cell proliferationIEA:Ensembl
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process hematopoietic stem cell proliferationIEA:Ensembl
Biological Process negative regulation of oocyte maturationIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process positive regulation of mitotic cell cycleIEA:Ensembl
Biological Process positive regulation of T-helper cell differentiationIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process T cell receptor signaling pathwayIEA:Ensembl

Cellular Location

Cytoplasm
Cell membrane
Associates with membrane lipid rafts upon TCR stimulation.

PTM

Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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