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Rabbit Anti-SHB Recombinant Antibody (CBXS-1592) (CBMAB-S4441-CQ)

This product is a rabbit antibody that recognizes SHB. The antibody CBXS-1592 can be used for immunoassay techniques such as: WB.
See all SHB antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1592
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Src homology 2 domain containing adaptor protein B
Entrez Gene ID
Human6461
Mouse230126
Rat362513
UniProt ID
HumanQ15464
MouseQ6PD21
RatD3ZN31
Alternative Names
SH2 Domain Containing Adaptor Protein B; SHB (Src Homology 2 Domain Containing) Adaptor Protein B; Src Homology 2 Domain Containing Adaptor Protein B; SHB Adaptor Protein (A Src Homology 2 Protein); SH2 Domain-Containing Adapter Protein B; BA3J10.2;
Function
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Biological Process
Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process B cell proliferationIEA:Ensembl
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process hematopoietic stem cell proliferationIEA:Ensembl
Biological Process negative regulation of oocyte maturationIEA:Ensembl
Biological Process negative regulation of protein kinase activityIEA:Ensembl
Biological Process positive regulation of mitotic cell cycleIEA:Ensembl
Biological Process positive regulation of T-helper cell differentiationIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process T cell receptor signaling pathwayIEA:Ensembl
Cellular Location
Cytoplasm
Cell membrane
Associates with membrane lipid rafts upon TCR stimulation.
PTM
Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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