SLC14A1

The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system.

Full Name

Solute Carrier Family 14 Member 1 (Kidd Blood Group)

Function

Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes (PubMed:7989337, PubMed:10514515, PubMed:7797558, PubMed:8997401).
Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity).
Facilitates water transport in erythrocytes (By similarity).

Biological Process

Biological Process establishment of localization in cellIEA:Ensembl
Biological Process transmembrane transportTAS:Reactome
Biological Process urea transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process urea transportManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Basolateral cell membrane
Restricted to the basolateral membrane in various portions of the urothelium.