SLC1A5

The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus.

Full Name

Solute Carrier Family 1 Member 5

Function

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227).
Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.

Biological Process

Biological Process amino acid transportTAS:Reactome
Biological Process glutamine secretionIEA:Ensembl
Biological Process glutamine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-aspartate import across plasma membraneISS:ARUK-UCL
Biological Process L-glutamine import across plasma membraneIEA:Ensembl
Biological Process neutral amino acid transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein homotrimerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process transport across blood-brain barrierISS:ARUK-UCL

Cellular Location

Cell membrane
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Topology

Cytoplasmic: 1-51
Helical: 52-81
Extracellular: 82-94
Helical: 95-116
Cytoplasmic: 117-130
Helical: 131-153
Extracellular: 154-224
Helical: 225-248
Cytoplasmic: 249-257
Helical: 258-285
Extracellular: 286-306
Helical: 307-328
Cytoplasmic: 329-333
Helical: 334-364
Extracellular: 365-373
Helical: 374-400
Cytoplasmic: 401-413
Helical: 414-447
Extracellular: 448-460
Helical: 461-482
Cytoplasmic: 483-541