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Rabbit Anti-SLC1A5 Recombinant Antibody (V501) (CBMAB-A4780-YC)

Provided herein is a Rabbit monoclonal antibody against Human Solute Carrier Family 1 Member 5. The antibody can be used for immunoassay techniques, such as WB, IP, IF, FC.
See all SLC1A5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
V501
Antibody Isotype
IgG
Application
WB, IP, IF, FC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 1 Member 5
Introduction
SLC1A5 is a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus.
Entrez Gene ID
Human6510
Mouse20514
Rat292657
UniProt ID
HumanQ15758
MouseP51912
RatD3ZJ25
Alternative Names
AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC
Function
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227).
Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.
Biological Process
Biological Process amino acid transportTAS:Reactome
Biological Process glutamine secretionIEA:Ensembl
Biological Process glutamine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-aspartate import across plasma membraneISS:ARUK-UCL
Biological Process L-glutamine import across plasma membraneIEA:Ensembl
Biological Process neutral amino acid transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein homotrimerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process transport across blood-brain barrierISS:ARUK-UCL
Cellular Location
Cell membrane
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Topology
Cytoplasmic: 1-51
Helical: 52-81
Extracellular: 82-94
Helical: 95-116
Cytoplasmic: 117-130
Helical: 131-153
Extracellular: 154-224
Helical: 225-248
Cytoplasmic: 249-257
Helical: 258-285
Extracellular: 286-306
Helical: 307-328
Cytoplasmic: 329-333
Helical: 334-364
Extracellular: 365-373
Helical: 374-400
Cytoplasmic: 401-413
Helical: 414-447
Extracellular: 448-460
Helical: 461-482
Cytoplasmic: 483-541
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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