SLC22A3

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.

Full Name

Solute Carrier Family 22 Member 3

Function

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

Biological Process

Biological Process dopamine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process epinephrine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process histamine metabolic processManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process histamine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process monoamine transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process monocarboxylic acid transportIEA:Ensembl
Biological Process neurotransmitter transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process norepinephrine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process organic anion transportISS:ARUK-UCL
Biological Process organic cation transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process purine-containing compound transmembrane transportTAS:Reactome
Biological Process quaternary ammonium group transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process regulation of appetiteIEA:Ensembl
Biological Process serotonin uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process toxin transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Biological Process xenobiotic transportManual Assertion Based On ExperimentIDA:ARUK-UCL

Cellular Location

Membrane