SNRPD1

This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Two transcript variants encoding different isoforms have been found for this gene.
Full Name
Small Nuclear Ribonucleoprotein D1 Polypeptide
Function
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346).
Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346).
Is also a component of the minor U12 spliceosome (PubMed:15146077).
May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (Probable)
Biological Process
Biological Process 7-methylguanosine cap hypermethylation1 PublicationIC:ComplexPortal
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA splicingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process spliceosomal complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Biological Process spliceosomal snRNP assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process U2-type prespliceosome assembly1 PublicationIC:ComplexPortal
Cellular Location
Cytoplasm, cytosol
Nucleus
SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
PTM
Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.
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Anti-SNRPD1 antibodies

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Mouse Anti-SNRPD1 Recombinant Antibody (ANA128) (CBMAB-S2929-CQ)

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Target: SNRPD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: ANA128
Application*: IF, IP, WB
Datasheet SDS

Human SNRPD1 ELISA Kit (V2LY-0626-LY5256)

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Target: SNRPD1
Sensitivity: 0.0099 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-SNRPD1 Recombinant Antibody (
24E2) (V2LY-0725-LY882)

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Target: SNRPD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 24E2
Application*: E, IH, IF, F
Datasheet SDS

Mouse Anti-SNRPD1 Recombinant Antibody (CBXS-3446) (CBMAB-S6177-CQ)

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Target: SNRPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3446
Application*: DB, WB
Datasheet SDS

Mouse Anti-SNRPD1 Recombinant Antibody (CBXS-0617) (CBMAB-S3559-CQ)

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Target: SNRPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0617
Application*: WB
Datasheet SDS

Mouse Anti-SNRPD1 Recombinant Antibody (ANA127) (CBMAB-S2928-CQ)

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Target: SNRPD1
Host: Mouse
Antibody Isotype: IgA, κ
Specificity: Human
Clone: ANA127
Application*: IF, IP, WB
Datasheet SDS

Mouse Anti-SNRPD1 Recombinant Antibody (CBXS-4673) (CBMAB-S1908-CQ)

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Target: SNRPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4673
Application*: DB, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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